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| Prolonged antigen presentation impacting on Tfh differentiation | |
|---|---|
| Files | naive_1 naive_2 200nm_2 200nm_3 y3p_2 y3p_3 200nm_1 y3p_1 |
| URL | elifesciences.org/content/4/e06994 |
| Creator | Robert Benson |
| Uploaded | 2015-12-18 |
| Description | DsRed OT-II T cells were adoptively transferred into CD11cYFP recipients and footpad challenged with 100 µg of OVA conjugated to 200 nm particles. Popliteal LNs were imaged 72 hours post challenge.2 hr prior to imaging, 200 nm challenged groups were given 500 µg mIgG2a or Y3P (anti-mouse I-A) to disrupt continued DC/T cell interactions. |
| Reference | Benson RA, MacLeod MK, Hale BG, Patakas A, Garside P, Brewer JM. Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. Elife. 2015 Aug 10;4. doi: 10.7554/eLife.06994. |
| DOI | 10.7554/eLife.06994 |